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Plasma sRAGE and Ang-2 levels stratified by PARDS severity Comparison was made between mild, moderate and severe PARDS versus control using the Mann-Whitney U test. P values are subjected to Bonferroni correction for multiple testing. Ang-2, angiopoietin-2; PARDS, paediatric acute respiratory distress syndrome; sRAGE, soluble receptor for advanced glycation end-products.

Journal: BMJ Open Respiratory Research

Article Title: Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome

doi: 10.1136/bmjresp-2025-003630

Figure Lengend Snippet: Plasma sRAGE and Ang-2 levels stratified by PARDS severity Comparison was made between mild, moderate and severe PARDS versus control using the Mann-Whitney U test. P values are subjected to Bonferroni correction for multiple testing. Ang-2, angiopoietin-2; PARDS, paediatric acute respiratory distress syndrome; sRAGE, soluble receptor for advanced glycation end-products.

Article Snippet: The plasma was then aspirated and stored at −80°C for later batched analysis. sRAGE (R&D Systems; catalogue no. DY1145) and Ang-2 (R&D Systems; catalogue no. DY623) were measured in duplicate using an ELISA according to manufacturer’s protocol.

Techniques: Clinical Proteomics, Comparison, Control, MANN-WHITNEY

Correlation matrix of plasma sRAGE and Ang-2 with age, PIM 3 score, PELOD2 score and the oxygenation index. Spearman test was used to assess correlation. Numbers in cells refer to Spearman’s correlation coefficient. *p<0.05, **p<0.01, ***p<0.001. Ang-2, angiopoietin-2; PELOD 2, Pediatric Logistic Organ Dysfunction 2 score; PIM 3, Pediatric Index of Mortality 3 score; sRAGE, soluble receptor for advanced glycation end-products.

Journal: BMJ Open Respiratory Research

Article Title: Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome

doi: 10.1136/bmjresp-2025-003630

Figure Lengend Snippet: Correlation matrix of plasma sRAGE and Ang-2 with age, PIM 3 score, PELOD2 score and the oxygenation index. Spearman test was used to assess correlation. Numbers in cells refer to Spearman’s correlation coefficient. *p<0.05, **p<0.01, ***p<0.001. Ang-2, angiopoietin-2; PELOD 2, Pediatric Logistic Organ Dysfunction 2 score; PIM 3, Pediatric Index of Mortality 3 score; sRAGE, soluble receptor for advanced glycation end-products.

Article Snippet: The plasma was then aspirated and stored at −80°C for later batched analysis. sRAGE (R&D Systems; catalogue no. DY1145) and Ang-2 (R&D Systems; catalogue no. DY623) were measured in duplicate using an ELISA according to manufacturer’s protocol.

Techniques: Clinical Proteomics

Plasma sRAGE and Ang-2 levels in the presence of cardiovascular dysfunction, multiorgan dysfunction and mortality. Data presented as median (IQR), and comparison was made using the Mann-Whitney test. Organ dysfunctions were defined according to the International Pediatric Sepsis Consensus Conference. Ang-2, angiopoietin-2; ICU, intensive care unit; sRAGE, soluble receptor for advanced glycation end-products.

Journal: BMJ Open Respiratory Research

Article Title: Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome

doi: 10.1136/bmjresp-2025-003630

Figure Lengend Snippet: Plasma sRAGE and Ang-2 levels in the presence of cardiovascular dysfunction, multiorgan dysfunction and mortality. Data presented as median (IQR), and comparison was made using the Mann-Whitney test. Organ dysfunctions were defined according to the International Pediatric Sepsis Consensus Conference. Ang-2, angiopoietin-2; ICU, intensive care unit; sRAGE, soluble receptor for advanced glycation end-products.

Article Snippet: The plasma was then aspirated and stored at −80°C for later batched analysis. sRAGE (R&D Systems; catalogue no. DY1145) and Ang-2 (R&D Systems; catalogue no. DY623) were measured in duplicate using an ELISA according to manufacturer’s protocol.

Techniques: Clinical Proteomics, Comparison, MANN-WHITNEY